Medical Uses
Hernexeos (zongertinib) is a kinase inhibitor used for the treatment of adult patients with unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC) whose tumors have HER2 (ERBB2) tyrosine kinase domain activating mutations, and who have previously been treated with systemic therapy.
Note: This indication is approved under accelerated approval based on objective response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial.
Recommended Dosage:
The recommended dosage of Zongertinib is taken orally once daily with or without food until there is evidence of disease progression or unacceptable toxicity. Swallow the tablets whole with water. It is not advisable to split, crush, or chew tablets.
The dosage based on body weight:
- < 90 kg: 120 mg
- ≥ 90 kg: 180 mg
If a dose is missed within 12 hours, take the dose. If a dose is missed by more than 12 hours, skip the missed dose and take the next scheduled dose. If any dose is vomited, do not take an additional dose. Take the next dose at the regularly scheduled time.