Xiaflex (Collagenase Clostridium Histolyticum)
- Medicine Name: Xiaflex
- Generic Name: Collagenase Clostridium Histolyticum
- Dosage Form & Strength: Single-use glass vials containing 0.9 mg
- Manufactured By: Endo Pharmaceuticals Inc.
Medical Uses: Xiaflex is a combination of bacterial collagenases used for the treatment of
adult patients with Dupuytren’s contracture (palmar fibromatosis) with a palpable cord.
adult males with Peyronie’s disease (penile fibrosis) with a palpable plaque and curvature deformity of minimum 30 degrees at the beginning of therapy.
Recommended Dosage: Dupuytren’s Contracture: Xiaflex should be administered by a health specialist experienced in injection procedures of the hand and in the treatment of Dupuytren’s contracture. Reconstitute Xiaflex lyophilized powder with only the supplied diluent before use. Xiaflex 0.58 mg should be injected into each palpable Dupuytren’s cord with a contracture of a metacarpophalangeal (MP) joint or a proximal interphalangeal (PIP) joint as per the injection procedure.
Up to a couple of joints in the same hand may be treated during a treatment visit. Around 24 to 72 hours following an injection, perform a finger extension procedure in case a contracture persists.
Injections and finger extension procedures may be given up to three times per cord at around 4-week intervals.
Inject up to a couple of cords in the same hand at a treatment visit. In case a patient has other cords with contractures, inject those cords at another treatment visit.
Peyronie’s Disease: Xiaflex injections for peyronie’s disease should be administered by a health specialist experienced in the treatment of male urological diseases.
Reconstitute Xiaflex lyophilized powder with only the supplied diluent before use.
A treatment cycle typically consists of 2-Xiaflex injection procedures and a penile modeling procedure. Induce a penile erection. A single intracavernosal injection of 10 or 20 micrograms of alprostadil may be considered for this purpose.
With the penis in the erect position, identify and mark the target area in the Peyronie’s plaque to be injected. The penis state should be flaccid prior to injecting this medicine.
Xiaflex 0.58 mg should be injected into the target plaque once on each of two days, 1 to 3 days apart, as per the injection procedure.
Penile modeling procedure should be performed 1 to 3 days following the second injection of each Peyronie’s disease treatment cycle.
For each plaque causing the curvature deformity, up to 4 treatment cycles can be administered. Each treatment cycle may be repeated at around 6-week intervals. In case the curvature deformity is below 15 degrees following the 1’st, 2’nd or 3’rd treatment cycle, or if further treatment is not clinically required, then administer the subsequent treatment cycles.
All Trademarks and Brands that appear on the website belong to their respective owners and indianpharmanetwork does not lay any claim on them we only provide Information.