Sephience (Sepiapterin)

Sephience (sepiapterin) is a phenylalanine hydroxylase (PAH) activator used for the treatment of hyperphenylalaninemia (HPA) in adult and pediatric patients aged 1 month and older with sepiapterin-responsive phenylketonuria (PKU). This therapeutic drug is to be used in conjunction with a phenylalanine (Phe)- restricted diet.

Recommended Dosage:
Patients receiving Sepiapterin should follow a dietary protein- and Phe-restricted diet. The medicine is administered orally once daily with food. The recommended starting dosage of Sepiapterin varies according to age. For infants aged less than 6 months, the dosage is 7.5 mg/kg daily. For children aged 6 months to less than 1 year, the dosage increases to 15 mg/kg daily. For those aged 1 year to less than 2 years, the dosage is 30 mg/kg daily. For patients aged 2 years and older, the recommended dosage is 60 mg/kg daily. For calculated daily doses of less than 1,000 mg, this medicine should be prepared as a liquid mixture with a concentration of 25 mg/mL, and the exact prescribed dose volume (in mL) must be administered.

• Treatment with Sepiapterin may increase the probability of bleeding, particularly in those taking anticoagulants or antiplatelet agents. Caution is required in individuals with clotting disorders or those undergoing surgery. Monitoring for signs and symptoms such as nosebleeds, unusual bruising, or prolonged bleeding is strongly recommended.
• Taking this medication can drop phenylalanine in the blood, which might cause hypophenylalaninemia—low phenylalanine levels. That's why kids on this treatment need blood checks to monitor phenylalanine levels. Keeping those levels steady means sticking to a balanced diet, getting the right medicine dose, and making any changes recommended by the healthcare team. Doing this keeps the brain safe and helps the treatment work the way it should.
• Sepiapterin can change how the body processes levodopa. This means levodopa may work stronger, weaker, or in a way that doctors didn’t expect. Because of this, anyone taking both sepiapterin and levodopa should have their treatment watched carefully. Look for changes in how well the levodopa works or for new side effects. The doctor might need to adjust the levodopa dose to keep the treatment both effective and safe.
• The safety of Sepiapterin for pregnant people isn't known yet. Research with animals is very limited, and we don't know exactly how it might affect the growing fetus. Because of this uncertainty, Sepiapterin should only be taken during pregnancy if it is absolutely necessary, and only after the possible good it can do for the mother is compared to the possible harm it could cause to the baby or to its future development.
• It is not specified whether this medicine is excreted into human breast milk. Because of potential effects on nursing infants, caution must be exercised. Clinicians must assess the necessity of treatment in mothers and consider discontinuing either the medicine or breastfeeding during treatment.

What documents are required to import SEPHIENCE to India?

SEPHIENCE (sepiapterin) oral powder can be imported by patients or government hospitals in the name of the patients only.
The following documentation is required to import the product:

• A valid prescription from a qualified doctor.
• Patients diagnostic reports
• Patient ID proof (issued by the government of India)

How does the order get confirmed?

The order will be confirmed only after the receipt of:

• A valid prescription from the Doctor
• Import permit if applicable

Is SEPHIENCE available in India?

SEPHIENCE (sepiapterin oral powder) is a (prescription drug, prescription medication, or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.

IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator, providing input

• On availability of Sephience in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune, etc.)
• On availability in Gulf countries (Bahrain, Oman, Qatar, Kuwait, Iraq, Saudi Arabia, and the UAE).
• Medicine Price.
• Finding Genuine and reliable sources from the USA, Canada, Europe, and Australia
• Ensuring 100% transparency.

SEPHIENCE can be made available to patients, doctors, and hospitals in Mumbai, Goa, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow, and Pune, and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and an import permit.

IPN (Indian Pharma Network) can facilitate the supply of SEPHIENCE (prescription medicines) to all locations in the world and India after fulfilling the legal requirements (if applicable).

Please contact +91-9310090915 | Toll-Free Number: 1800-889-1064 or write us at info@indianpharmanetwork.in for Sephience 250 mg/1000 mg price in India.

We guarantee quality and delivery anywhere in the world as per the buyer’s requirements.

Indian Pharma Network can source SEPHIENCE (Cancer Treatment Medicines) from across the globe and can supply. Indian Pharma offers its customers worldwide access to the best available treatment.

Indian Pharma Network (IPN) can dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient's address only from New Delhi, India.

What is the Generic Name for the trade name drug Sephience®?

Sepiapterin is the Generic Name for the trade name drug Sephience®.

What is the Manufacturer's Name of Sephience®?

Sephience® is manufactured by Allphamed PHARBIL Arzneimittel GmbH.

Is Sephience approved by the FDA?

Yes, Sephience is approved by the FDA. Date of first approval: July 28, 2025.

What is the dosage and form of Sephience® supplied?

Sephience is supplied in Oral Powder: 250 mg and 1000 mg for oral use. It is designed to treat patients with phenylketonuria.

What are the most common side effects of Sephience® 250 mg/1000 mg Oral Powder?

The most commonly reported side effects of Sephience® 250 mg/1000 mg oral powder are diarrhea, feces discoloration, headache, hypophenylalaninemia, abdominal pain, and oropharyngeal pain.

How much does Sephience® 250 mg/1000 mg Oral Powder cost in India?

Sephience® is not yet approved in India. However, patients in India can legally access it through the provision called the Named Patient Program (NPP). Prices of Sephience Oral Powder may fluctuate over time because of market dynamics and regulatory changes. For the most transparent and latest Sephience 250 mg/1000 mg cost in India, please call/WhatsApp +91-9310090915 or send an email to info@indianpharmanetwork.in.

Can Sephience® 250 mg/1000 mg Oral Powder be available in SAARC countries?

Apart from Gulf countries, Sephience® can be accessed through import provisions like the Named Patient Program (NPP) in SAARC countries (India, Afghanistan, Maldives, Nepal, Bangladesh, Bhutan, Pakistan, and Sri Lanka). Indian Pharma Network (IPN) can help facilitate the legal supply of Sephience® Oral Powder in these countries. We help provide legal access to this therapeutic drug through our reliable channels.

Is it safe to buy Sephience® 250 mg/1000 mg oral powder online in India?

Yes, one can buy Sephience 250 mg/1000 mg online in India at the lowest price from the Indian Pharma Network (IPN) if this medicinal product is not yet registered or available in their country. We can help facilitate the legal supply of Sephience® oral powder through legal channels.

What are the storage conditions of Sephience® 250 mg/1000 mg Oral Powder?

Store it at room temperature between 20°C to 25°C (68°F to 77°F); excursion permitted between 15°C to 30°C (59°F to 86°F).