Medical Uses
TNKase (tenecteplase: a modified form of human tissue plasminogen activator (tPA) that works by breaking down fibrin, a component of blood clots) is a tissue plasminogen activator (tPA) used:
- for the treatment of acute ischemic stroke (AIS) in adults.
- to reduce the risk of death associated with acute ST elevation myocardial infarction (STEMI) in adults.
Recommended Dosage:
The recommended dosage of TNKase is for intravenous (IV) administration only, administered as a single bolus over 5 seconds.
- Acute Ischemic Stroke (AIS): Start treatment as promptly as possible and within 3 hours after the onset of stroke symptoms. Individualize the dosage of this therapeutic drug based on the patient’s weight. The maximum recommended dose of TNKase is 25 mg (5 mL).
- Acute STEMI: Start treatment as promptly as possible after the onset of acute ST elevation myocardial infarction (STEMI) symptoms. Individualize the dosage of this therapeutic drug based on the patient’s weight. The maximum recommended dose of TNKase is 50 mg (10 mL).