Xenpozyme (Olipudase alfa-rpcp)

Xenpozyme (olipudase alfa-rpcp) is a hydrolytic lysosomal sphingomyelin-specific enzyme indicated for the treatment of non–central nervous system manifestations of acid sphingomyelinase deficiency (ASMD) in adult and pediatric patients.

Recommended Dosage:
The recommended dosage of Olipudase alfa-rpcp should be determined in consultation with physicians experienced in the management of ASMD. To avoid dosing errors, including overdosage, follow all instructions for dosage and administration. Obtain baseline transaminase (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) levels in all patients within 30 days before treatment initiation. Verify pregnancy status in females of reproductive potential.

The recommended adult and pediatric dosages for the dose escalation and maintenance phases are based on body weight as follows for patients with a body mass index (BMI):

• For less than or equal to 30, the dosage is based on actual body weight (kg)
• For those greater than 30, the dosage is based on adjusted body weight (kg). Calculate an adjusted body weight (kg) based on height in meters.

• Some patients can develop severe allergic reactions, even going into anaphylaxis. Warning signs are trouble breathing, a rash, swelling, or very low blood pressure. If you see any of these, stop the drip right away and call for emergency help. It's important to watch the person carefully while the dose runs and for a while after.
• Treatment with Olipudase alfa-rpcp may cause reactions during or after infusion. Symptoms can include nausea, fever, chills, headache, or fatigue. Infusions need to be administered under medical supervision. Pre-medication and slowing the infusion rate may reduce the severity of such reactions.
• Liver enzyme levels (AST and ALT) may increase during treatment. Regular blood tests are important to check liver function. If levels become too high, your healthcare provider may lower the dose or pause treatment until liver levels return to a safe range.
• Starting or increasing the Olipudase alfa-rpcp dose during pregnancy may cause harm to the unborn baby. Animal findings demonstrated birth defects. Women who are pregnant should discuss potential risks with their healthcare provider (HCP) before starting or increasing treatment.
• There is limited information on the use of this therapeutic drug in pregnant women. Because of the possible risk to the fetus, use this drug only if clearly required. Healthcare providers (HCPs) should carefully weigh the benefits and risks before starting treatment in pregnant patients.
• It is unknown if Olipudase alfa-rpcp passes 4 mg/20 mg into breast milk. Caution is required for breastfeeding mothers. A decision should be made whether to stop breastfeeding or discontinue treatment, depending on the importance of the drug to the mother.
• Women of childbearing potential should use effective birth control during treatment. Men and women planning to conceive should consult their healthcare provider (HCP). Risks associated to pregnancy must be discussed before starting treatment or if pregnancy occurs during therapy.

What documents are required to import XENPOZYME to India?

XENPOZYME (olipudase alfa-rpcp) injections can be imported by patients or government hospitals in the name of the patients only.
The following documentation is required to import the product:

• A valid prescription from a qualified doctor.
• Patients diagnostic reports
• Patient ID proof (issued by the government of India)

How does the order get confirmed?

The order will be confirmed only after the receipt of:

• A valid prescription from the Doctor
• Import permit if applicable

Is XENPOZYME available in India?

XENPOZYME (olipudase alfa-rpcp injections) is a (prescription drug, prescription medication, or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.

IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator, providing input

• On availability of Xenpozyme in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune, etc.)
• On availability in Gulf countries (Bahrain, Oman, Qatar, Kuwait, Iraq, Saudi Arabia, and the UAE).
• Medicine Price.
• Finding Genuine and reliable sources from the USA, Canada, Europe, and Australia
• Ensuring 100% transparency.

XENPOZYME can be made available to patients, doctors, and hospitals in Mumbai, Goa, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow, and Pune, and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and an import permit.

IPN (Indian Pharma Network) can facilitate the supply of XENPOZYME (prescription medicines) to all locations in the world and India after fulfilling the legal requirements (if applicable).

Please contact +91-9310090915 | Toll-Free Number: 1800-889-1064 or write us at info@indianpharmanetwork.in for Xenpozyme 4 mg/20 mg injection price in India.

We guarantee quality and delivery anywhere in the world as per the buyer’s requirements.

Indian Pharma Network can source XENPOZYME (Cancer Treatment Medicines) from across the globe and can supply. Indian Pharma offers its customers worldwide access to the best available treatment.

Indian Pharma Network (IPN) can dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient's address only from New Delhi, India.

What is the Generic Name for the trade name drug Xenpozyme®?

Olipudase alfa-rpcp is the Generic Name for the trade name drug Xenpozyme®.

What is the Manufacturer's Name of Xenpozyme®?

Xenpozyme® is manufactured by Genzyme Corporation

Is Xenpozyme® approved by the FDA?

Yes, Xenpozyme® is approved by the FDA. Date of first approval: August 31, 2022.

What is the dosage and form of Xenpozyme® supplied?

Xenpozyme is supplied for injection: 4 mg or 20 mg of olipudase alfa-rpcp as a lyophilized powder in a single-dose vial for reconstitution for intravenous (IV) use.

What are the most common side effects of Xenpozyme® 4 mg/20 mg injection?

The most common side effects of Xenpozyme® in
adult patients: headache, cough, diarrhea, hypotension, and ocular hyperemia.
pediatric patients: pyrexia, diarrhea, rhinitis, cough, abdominal pain, vomiting, urticaria, nausea, headache, rash, fatigue, arthralgia, pruritus, and pharyngitis

How much does Xenpozyme® 4 mg/20 mg injection cost in India?

Prices of Xenpozyme injections may fluctuate over time because of market dynamics and regulatory changes. For the most transparent and latest Xenpozyme 4 mg/20 mg cost in India, please call/WhatsApp +91-9310090915 or send mail to info@indianpharmanetwork.in.

Can Xenpozyme® 4 mg/20 mg injections be available in SAARC countries?

Apart from Gulf countries, Xenpozyme® can be available in SAARC countries (India, Afghanistan, Maldives, Nepal, Bangladesh, Bhutan, Pakistan, and Sri Lanka). Indian Pharma Network (IPN) can help facilitate the legal supply of Xenpozyme® injection in these countries. We help provide legal access to this therapeutic drug through our reliable channels.

Is it safe to buy Xenpozyme® 4 mg/20 mg injection online in India?

Yes, one can buy Xenpozyme 4 mg/20 mg online in India at the lowest price from the Indian Pharma Network (IPN) if this medicinal product is not (yet) registered or available in their country. We can help facilitate the legal supply of Xenpozyme® injection through legal channels.

What are the storage conditions of Xenpozyme® 4 mg/20 mg injections?

Store this therapeutic drug refrigerated at 2°C to 8°C (36°F to 46°F). It is not advisable to freeze this medicine.