Alprolix - Coagulation Factor IX (recombinant)

Alprolix, Coagulation Factor IX (Recombinant), Fc Fusion Protein, is a recombinant DNA derived coagulation Factor IX concentrate used in adults and children with hemophilia B for:

• On-demand treatment and control of bleeding episodes,
  
• Perioperative management of bleeding,
  
• Routine prophylaxis to decrease the frequency of bleeding episodes.

Limitation of Use: This therapeutic drug is not for induction of immune tolerance in patients with hemophilia B.

Recommended Dosage: 

On-demand Treatment and Control of Bleeding Episodes: The initial recommended dose for minor and moderate bleeding is 30-60 IU/dL. Repeat the dose every 48 hours as needed if there is further evidence of bleeding. The recommended dose for major bleeding is 80-100 IU/dL. Repeat the dose after 6 to 10 hours, then every 24 hours for 3 days, then every 48 hours until healing is achieved.

Perioperative management: A single infusion to reach a FIX level of 50-80 IU/dL may be sufficient during minor surgery. Repeat as required after 24 to 48 hours until bleeding stops and healing is achieved. Initial infusion to reach a FIX level of 60-100 IU/dL may be sufficient during major surgery. Repeat the dose after 6 to 10 hours and then every 24 hours for the initial 3 days, then every 48 hours until bleeding stops and healing is achieved.

Routine prophylaxis: For adults and adolescents aged ≥12 years, start at 50 IU/kg once weekly or 100 IU/kg once every 10 days. For children aged <12 years, start at 60 IU/kg once weekly. Adjust the dosing regimen on behalf of individual response. More frequent or higher doses may be required in children aged <12 years.

• Allergic-type hypersensitivity reactions, including anaphylaxis, may occur with Alprolix. Evaluate patients experiencing allergic reactions for the existence of an inhibitor. Stop using treatment if hypersensitivity symptoms occur, and start appropriate treatment. 
  
• Formation of neutralizing antibodies (inhibitors) to Factor IX may occur following administration of Alprolix, Coagulation Factor IX (Recombinant). Monitor all patients on a regular basis for the development of inhibitors by relevant clinical observations and laboratory.
  
• To confirm appropriate Factor IX levels have been achieved and maintained, monitor patient plasma Factor IX levels by performing a validated one-stage clotting assay. Factor IX results can be affected by the type of aPTT reagent used. Measurement with a one-stage clotting assay using a kaolin-based aPTT reagent has been shown to result in an underestimation of Factor IX levels.
  
• Monitor for the establishment of Factor IX inhibitors if the expected Factor IX levels in patient plasma are not attained, or if bleeding is not controlled with the recommended dose of Alprolix. Perform a Bethesda assay to specify if Factor IX inhibitors are present.
  
• Nephrotic syndrome may occur following attempted immune tolerance induction in hemophilia B patients with Factor IX inhibitors. The safety and efficacy of using this medicinal product for immune tolerance induction have not been established.
  

What documents are required to import ALPROLIX to India?

ALPROLIX, Coagulation Factor IX (Recombinant) can be imported by patients or government hospitals on the name of the patients only. 

The following documentation is required to import the product:

• A valid prescription from a qualified doctor.
  
• Patients diagnostic reports
  
• Patients ID proof (issued by the government of India)
  

How does the order be confirmed?

The order will be confirmed only after the receipt of:

• A valid prescription from Doctor
  
• Import permit if applicable

ALPROLIX, Coagulation Factor IX (Recombinant) is a (prescription drug, prescription medication, or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.

IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator providing input

• On availability of Alprolix in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune etc.)
  
• Medicine Price.
  
• Finding Genuine and reliable sources from the USA, Canada, Europe, and Australia
  
• Ensuring 100% transparency.

IPN (Indian Pharma Network) can facilitate the supply of ALPROLIX (prescription medicines) to all locations in the world and in India after fulfilling the legal requirement (if applicable).

Please contact +91-9310090915 | Toll-Free Number: 1800-889-1064 or write us at info@indianpharmanetwork.in for Alprolix price in India. 

We take to guarantee quality and delivery anywhere in the world as per the buyer’s requirements.

Indian Pharma Network is able to source the ALPROLIX (Cancer Treatment Medicines) from across the globe and has the ability to supply. Indian Pharma offers its customers worldwide access to the best available treatment.

Indian Pharma Network is able to dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient’s address only from New Delhi, India.

What is the Generic Name for the trade name drug Alprolix®?

Coagulation factor IX (recombinant) is a Generic Name for the trade name drug Alprolix®.

What is the Manufacturer’s Name of Alprolix®?

Alprolix® is manufactured by Bioverativ Therapeutics Inc.

Is Alprolix® approved by the FDA?

Yes, Alprolix® is approved by the FDA. Date of first approval: March 28, 2014.

What is the dosage and form of Alprolix® supplied?

Alprolix® is supplied as a lyophilized powder in single-dose vials containing nominally 250, 500, 1000, 2000, 3000, or 4000 international units for intravenous injection. 

What are the most common side effects of Alprolix®? 

The most common side effects of Alprolix® are headache, oral paresthesia,  injection site erythema, hypersensitivity, and obstructive uropathy.

How much does Alprolix® cost in India?

The cost of Alprolix in India can vary. To procure this injectable drug legally, you can call or WhatsApp +91-9310090915 or send mail to info@indianpharmanetwork.in.

What are the storage conditions of Alprolix®?

Store in the original package to protect it from light at 2°C to 8°C (36°F to 46°F). Do not freeze it. Freezing will be responsible for damage to the prefilled diluent syringe.

Is it safe to buy Alprolix® online in India?

Yes, one can buy Alprolix online in India at the lowest price from the Indian Pharma Network (IPN) if this medicinal product is not (yet) registered or available in their country. We can help facilitate the supply of Alprolix® through legal channels.