Alprolix (Eftrenonacog Alfa)

Alprolix (eftrenonacog alfa) is a recombinant, extended half-life Factor IX replacement therapy from Sanofi (Bioverativ), indicated in adults and children with hemophilia B (congenital Factor IX deficiency) for routine prophylaxis to reduce the frequency of bleeding episodes, for on-demand control of bleeding episodes, and for perioperative (surgical) bleed management.

Alprolix is a recombinant Factor IX molecule genetically fused to the Fc portion of human IgG1, extending its circulating half-life compared with standard Factor IX products and allowing prophylactic dosing as infrequently as once every 7-10 days for many patients.

• Hypersensitivity reactions, including anaphylaxis, have been reported — stop infusion and seek medical attention if allergic symptoms occur.
• Development of neutralizing antibodies (inhibitors) to Factor IX is possible; monitor for reduced clinical response.
• Nephrotic syndrome has been reported in hemophilia B patients with Factor IX inhibitors undergoing immune tolerance induction.
• Common side effects include headache, bruising at infusion sites, and oral paraesthesia.

What documents are required to import Alprolix to India?

Alprolix may be imported in the patient’s name only, by patients or government hospitals. The following documentation is required:

• A valid prescription from a registered hematologist
• Diagnostic report confirming hemophilia B and baseline factor level
• Patient ID proof (issued by the Government of India)

How is the order confirmed?

The order is confirmed only after receipt and verification of a valid prescription from the doctor and an import permit, if applicable.

Is Alprolix available in India?

Alprolix is a prescription biologic that legally requires a doctor’s prescription to be dispensed. It is not commercially marketed in India. However, patients in India can legally access Alprolix through the Named Patient Program (NPP), an import provision that allows a medicine not yet registered in India to be imported for an individual patient’s personal treatment.

Indian Pharma Network (IPN) can source Alprolix from reliable channels across the world and facilitate supply to patients, doctors, and hospitals, offering worldwide access to this treatment under applicable legal provisions. Alprolix requires cold-chain handling (refrigerated 2-8°C); IPN uses temperature-monitored logistics for every shipment.

For Alprolix cost in India and availability, contact IPN at Phone: +91-9310090915 or email info@indianpharmanetwork.in.

Global Approval Status:

• United States: Approved by the FDA — March 2014.

What is the generic name for the brand drug Alprolix?

Eftrenonacog alfa is the generic name for the brand drug Alprolix.

What is Alprolix used for?

Alprolix is a Factor IX replacement therapy used to prevent and control bleeding episodes in people with hemophilia B.

Who manufactures Alprolix?

Alprolix is manufactured by Sanofi (Bioverativ).

How often is Alprolix dosed?

Most patients on prophylaxis dose once every 7 days, though the exact interval and amount are individualized by the treating hematologist.

How much does Alprolix cost in India?

Cost depends on vial strength, prophylactic dosing frequency, and sourcing logistics. Share the hematologist’s prescription with IPN for an itemized quote.