Chenodeoxycholic Acid Leadiant (Chenodeoxycholic Acid)

Chenodeoxycholic Acid Leadiant is authorised in the European Union for inborn errors of primary bile acid synthesis due to sterol 27-hydroxylase deficiency, which presents as cerebrotendinous xanthomatosis (CTX), in infants, children, adolescents and adults. CTX is a rare inherited disorder in which cholestanol builds up in the brain, tendons and other tissues, causing diarrhoea, cataracts, tendon xanthomas and progressive neurological problems.

Chenodeoxycholic acid replaces the bile acid that patients with CTX cannot make. This switches off the abnormal over-production of bile acid precursors through feedback inhibition, lowering cholestanol levels and helping to stabilise or improve symptoms when started early. The usual adult dose is 750 mg per day divided into three doses.

• Liver function tests should be done before and during treatment, as liver injury can occur.
• Possible side effects include diarrhoea and constipation; doses may need adjustment based on blood and urine bile alcohol and cholestanol levels.
• Bile acid sequestrants, aluminium-containing antacids, ciclosporin and some other medicines can interact with it.
• Women of childbearing potential should use effective contraception; it is not recommended during pregnancy.

What documents are needed to import Chenodeoxycholic Acid Leadiant into India?

Chenodeoxycholic Acid Leadiant is imported in the patient’s name, either by the patient or by a hospital. We will ask for:

• A valid prescription from a registered neurologist, metabolic specialist or hepatologist
• Genetic (CYP27A1) or biochemical report confirming cerebrotendinous xanthomatosis
• Patient ID proof issued by the Government of India

When is the order confirmed?

Only after we have received and checked a valid prescription.

Can I buy Chenodeoxycholic Acid Leadiant in India?

Chenodeoxycholic Acid Leadiant is an imported medicine and is not readily available through regular pharmacies in India. It can still be accessed legally on a named-patient basis, subject to Indian import regulations.

IPN helps patients and hospitals in India obtain Chenodeoxycholic Acid Leadiant from authorised international suppliers, handling the import paperwork under the Named Patient route.

To ask about Chenodeoxycholic Acid Leadiant cost and availability, reach us on +91-9310090915 or write to info@indianpharmanetwork.in.

Global Approval Status:

• European Union: Authorised in April 2017 (orphan medicine) for CTX.
• United States: Chenodiol for CTX is FDA-approved under a different brand (Ctexli, February 2025).

Why is Chenodeoxycholic Acid Leadiant prescribed?

Doctors prescribe Chenodeoxycholic Acid Leadiant for cerebrotendinous xanthomatosis (CTX). It is a primary bile acid replacement therapy.

Who is the maker of Chenodeoxycholic Acid Leadiant?

It is made by Leadiant Biosciences.

How does Chenodeoxycholic Acid act in the body?

Chenodeoxycholic acid replaces the bile acid that patients with CTX cannot make.

Is chenodeoxycholic acid the same as ursodeoxycholic acid?

No. They are different bile acids; for CTX, chenodeoxycholic acid is the standard treatment because it corrects the specific bile acid deficiency.

Is Chenodeoxycholic Acid Leadiant FDA approved?

Not under this brand name. In the US, chenodiol for CTX is approved as Ctexli (Mirum Pharmaceuticals).