Demser (Metyrosine)

Demser (metyrosine) is used in patients with pheochromocytoma, a tumour of the adrenal gland that releases excess adrenaline-like hormones. It is used to prepare patients for surgery, to manage patients when surgery is not possible, and for long-term treatment of malignant pheochromocytoma. It is not recommended for essential hypertension.

Metyrosine blocks tyrosine hydroxylase, the enzyme that controls the first step in making catecholamines (dopamine, noradrenaline and adrenaline). This reduces catecholamine production by 35 to 80 percent, helping to control high blood pressure and related symptoms. The usual starting dose is 250 mg four times daily.

• Sedation is very common, especially at the start of treatment.
• Patients should drink enough fluid (at least 2 litres a day) to prevent crystals in the urine.
• Extrapyramidal symptoms (such as drooling, tremor and speech difficulty), anxiety, depression, confusion and diarrhoea can occur.
• Alcohol and other CNS depressants add to sedation; phenothiazines and haloperidol may increase extrapyramidal effects.

What documents are needed to import Demser into India?

Demser is imported in the patient’s name, either by the patient or by a hospital. We will ask for:

• A valid prescription from a registered endocrinologist
• Biochemical and imaging report confirming pheochromocytoma
• Patient ID proof issued by the Government of India

When is the order confirmed?

Only after we have received and checked a valid prescription.

Can I buy Demser in India?

Demser is an imported medicine and is not readily available through regular pharmacies in India. It can still be accessed legally on a named-patient basis, subject to Indian import regulations.

IPN helps patients and hospitals in India obtain Demser from authorised international suppliers, handling the import paperwork under the Named Patient route.

To ask about Demser cost and availability, reach us on +91-9310090915 or write to info@indianpharmanetwork.in.

Global Approval Status:

• United States: FDA-approved for pheochromocytoma.

Why is Demser prescribed?

Doctors prescribe Demser for pheochromocytoma. It is a tyrosine hydroxylase inhibitor.

Who is the maker of Demser?

It is made by Bausch Health.

How does Metyrosine act in the body?

Metyrosine blocks tyrosine hydroxylase, the enzyme that controls the first step in making catecholamines (dopamine, noradrenaline and adrenaline).

Can Demser replace surgery?

No. It is mainly used to control symptoms before surgery or when surgery is not possible; surgery remains the main treatment for pheochromocytoma.

Is Demser FDA approved?

Yes. Demser (metyrosine) is FDA-approved for patients with pheochromocytoma.