Lucaftor (Lumacaftor/Ivacaftor)

Lucaftor (lumacaftor/ivacaftor) is a fixed-dose combination CFTR modulator therapy indicated for the treatment of cystic fibrosis (CF) in patients who are homozygous for the F508del mutation in the CFTR gene.

Lumacaftor helps correct the misfolded CFTR protein so it can move to the cell surface, while ivacaftor acts as a potentiator, helping the CFTR protein at the cell surface function more effectively — together improving chloride channel activity and helping reduce the buildup of thick, sticky mucus characteristic of CF.

• Elevated liver function tests (transaminases) have been reported; monitoring liver function before and during treatment is recommended.
• Risk of respiratory reactions (chest tightness, dyspnea), particularly in the initial days of treatment.
• Blood pressure increases have been observed in some patients; monitor periodically.
• Cataracts (non-congenital lens opacities) have been reported in pediatric patients; ophthalmological exams are recommended.
• Drug interactions: lumacaftor is a strong CYP3A inducer and can reduce the effectiveness of many other medicines, including hormonal contraceptives.

What documents are required to import Lucaftor to India?

Lucaftor may be imported in the patient’s name only, by patients or government hospitals. The following documentation is required:

• A valid prescription from a registered pulmonologist confirming CF and F508del homozygous genotype
• Genetic test report confirming the CFTR mutation status
• Patient ID proof (issued by the Government of India)

How is the order confirmed?

The order is confirmed only after receipt and verification of a valid prescription and genetic test report.

Is Lucaftor available in India?

Lucaftor is not commercially marketed in India. It can be legally accessed through the Named Patient Program (NPP).

Indian Pharma Network (IPN) can source Lucaftor from its authorized distribution network and facilitate supply to patients, doctors, and hospitals under applicable legal provisions.

For Lucaftor cost in India and availability, contact IPN at Phone: +91-9310090915 or email info@indianpharmanetwork.in.

Global Approval Status:

• United States: Approved by the FDA (as Orkambi) for CF patients homozygous for F508del.

What is Lucaftor used for?

Lucaftor treats cystic fibrosis in patients homozygous for the F508del CFTR mutation.

Who manufactures Lucaftor?

Lucaftor (lumacaftor/ivacaftor) is a CFTR modulator combination, the same active combination marketed as Orkambi.

How is Lucaftor taken?

Orally, typically twice daily with fat-containing food, as prescribed by the treating pulmonologist.

How much does Lucaftor cost in India?

Cost depends on monthly quantity and sourcing logistics — share your prescription with IPN for a quote.