Nyxoid (Naloxone)

Nyxoid (naloxone) is a ready-to-use nasal spray for the emergency treatment of known or suspected opioid overdose, seen as slowed breathing or reduced consciousness. It is for adults and adolescents aged 14 and over, and is meant for use in both home and healthcare settings, for example by a trained family member or carer while waiting for an ambulance.

Naloxone blocks opioid receptors, quickly reversing the effects of opioids such as heroin, morphine and fentanyl, including dangerous breathing problems. One spray goes into one nostril. If there is no response after 2–3 minutes, a second dose is given with a new spray in the other nostril; if the person wakes and then slips back, the second dose is given straight away.

• Always call an ambulance. Naloxone wears off sooner than many opioids, so overdose signs can come back.
• It can cause sudden opioid withdrawal (agitation, vomiting, sweating, fast heartbeat) in people who are dependent on opioids.
• With buprenorphine overdose the reversal may be incomplete, and breathing may need to be supported.
• Absorption may be affected if the inside of the nose is damaged. Safety and effectiveness below 14 years have not been established.

Who usually orders Nyxoid?

Families of people who take strong opioids, for pain or because of opioid dependence, often keep Nyxoid at home in case of an overdose. Doctors and de-addiction centres may also keep it in stock.

What is in the pack?

Each carton has 2 single-dose nasal sprays, each sealed in its own blister, with a quick-start guide printed on the back. Each spray holds only one dose, so it must not be tested or primed. The second spray is there in case a repeat dose is needed.

What documents do we need?

• A prescription from the treating doctor
• A short note on why it is needed, for example long-term opioid treatment
• Government-issued photo ID of the patient

We confirm the order only after the prescription has been checked.

How should Nyxoid be stored?

Do not let it freeze; the label gives no other temperature condition, and the shelf life is 3 years. Keep both sprays together in the carton, somewhere everyone in the house knows about, and check the expiry date from time to time.

Nyxoid is a small, room-temperature item. We source it from authorised distributors and check that it arrives with plenty of shelf life left, since it may sit unused at home for a long time.

For Nyxoid price in India, call +91 96548 60915 or +91 93100 90915, WhatsApp +91 98104 69557 or email info@indianpharmanetwork.in.

Global Approval Status:

• European Union: Authorised in November 2017 (Mundipharma); the authorisation was renewed in 2022.
• United Kingdom: Authorised (Napp Pharmaceuticals).
• United States: Nyxoid is not FDA-approved; other naloxone nasal sprays such as Narcan are.

Sources:

• Nyxoid – EMA EPAR (authorisation and holder)
• Nyxoid – EU product information (SmPC and leaflet)
• Nyxoid 1.8 mg – UK SmPC (Napp, eMC)

Information last checked: October 2026.

What is Nyxoid used for?

Nyxoid (naloxone) is an opioid antagonist nasal spray used for emergency treatment of known or suspected opioid overdose.

Who manufactures Nyxoid?

Nyxoid is from Mundipharma (EU); Napp Pharmaceuticals (UK).

How does Nyxoid work?

Naloxone blocks opioid receptors, quickly reversing the effects of opioids such as heroin, morphine and fentanyl, including dangerous breathing problems.

Who can give Nyxoid?

A trained family member or carer can give it. The label says anyone likely to use it should first be shown how and when to use it, and an ambulance must always be called.

Should we test-spray Nyxoid at home?

No. Each spray holds only one dose, so testing it empties it. Learn the steps from the leaflet, the guide on the back of the blister or the training video instead.

Is Nyxoid approved by the US FDA?

Nyxoid itself is not FDA-approved. In the US, other naloxone nasal sprays such as Narcan are FDA-approved.