The drug, Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase that is used as the additional dietary restriction of Tyrosine and Phenylalanine for treating hereditary tyrosinemia type 1 (HT-1).
Recommended dosage : Healthcare professionals recommend a dose of Orfadin as 1 to 2 mg/kg divided into 2 daily doses. And the initial dose is 1 mg/kg/day, divided into morning and evening administration.
Note: Orfadin is an FDA-approved drug.
Warning & Precautions
The drug, Nitisinone, is an inhibitor of 4-hydroxyphenyl-pyruvate dioxygenase, an enzyme in the tyrosine metabolic pathway. Therefore, treatment with Nitisinone may cause an increase in blood tyrosine in patients with HT-1, and patients should maintain a concomitant reduction in dietary tyrosine and phenylalanine while on Nitisinone treatment. One should maintain plasma tyrosine levels below 500 mol/L.
- Ocular signs and symptoms are reported in patients treated with Nitisinone, such as corneal ulcers, keratitis, conjunctivitis, corneal opacities, eye pain, and photophobia.
- Few patients who took Nitisinone experienced an abrupt change in neurologic status.
- Patients also experienced painful hyperkeratotic plaques on the soles and palms.
Reports show patients treated with Nitisinone and dietary restriction developed transient leucopenia, thrombocytopenia, or both. There is one case where a patient developed leukopenia and thrombocytopenia improved after the dose of Nitisinone decreased from 2 mg/kg to 1 mg/kg. One should monitor platelet, and white blood cell counts regularly during Nitisinone therapy.
Documentation & Availability
What documents are required to import Orfadin to India?
Orfadin (Nitisinone) can be imported only by patients or government hospitals under the patients’ names.
The following documentation is needed to import the product:
- A valid prescription from a qualified doctor.
- Patients diagnostic reports
- Patients Identity proof (issued by Govt of India)
How does the order confirm?
The order will be confirmed only after the receipt of:
- A valid prescription by healthcare professionals.
- Import permit if applicable.
Is ORFADIN available in India?
ORFADIN (Nitisinone capsules) is a (prescription drug, prescription medication or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.
IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator providing input
- On availability of Orfadin in India.
- Medicine Price.
- Finding Genuine and reliable sources from Canada, Europe, the USA and Australia.
- Ensuring 100% transparency.
Orfadin can be made available to patients, doctors and hospitals in Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow and Pune and other cities in India. The order will be confirmed only after receiving a valid prescription from the doctor and import permit.
IPN (Indian Pharma Network) can facilitate the supply of Orfadin (prescription medicines) to all locations in the world and India after fulfilling the legal requirement (if applicable)
Please get in touch with +91-9310090915 | Toll-Free No: 1800-889-1064 or write us at firstname.lastname@example.org for Alunbrig price in India.
We guarantee quality and delivery worldwide per the buyer’s requirements.
Sourcing & Delivery
Indian Pharma Network can source the ORFADIN from across the globe and can supply. Indian Pharma offers its customers worldwide access to the best available treatment.
Indian Pharma Network can dispense any valid prescription in the shortest span of time possible. All prescriptions are dispensed, checked by certified pharmacists, and dispatched to the Patient’s address only from New Delhi, India.
Indian Pharma Network helps to connect the patients with potential distributors, wholesalers, suppliers and dealers of Orfadin in India.
What is the Generic Name for the trade name drug Orfadin®?
Nitisinone is the generic name for the drug Orfadin.
What is the dosage of Nitisinone?
The drug Nitisinone is available in 2 mg, 5 mg, 10 mg and 20 mg capsules.
What is Orfadin used for?
The medicine Orfadin (Nitisinone) is used as an adjunct to dietary restriction of tyrosine and phenylalanine in the treating of hereditary tyrosinemia type 1 (HT-1).
How much does Orfadin cost in India?
To know the Orfadin (Nitisinone) cost in India, you can call or WhatsApp +91-9310090915 or email email@example.com.
Is there any generic or biosimilar available for Orfadin 10 mg?
There is no generic or biosimilar for Orfadin 10 mg globally.
What are the common side-effects of Orfadin?
The common side-effects of Orfadin are thrombocytopenia, leukopenia, conjunctivitis, corneal opacity, blepharitis, keratitis, photophobia, eye pain, cataracts, exfoliative dermatitis, granulocytopenia, epistaxis, pruritus, dry skin, maculopapular rash and alopecia.
What are the other brands under which Nitisinone is sold?
The drug Nitisinone is also sold under other innovator brand names such as Tisinon.
What are the Highlights of prescribing information for Nitisinone?
Click Here to download full Nitisinone prescribing information