Erwinase (Crisantaspase)

Erwinase (crisantaspase) is an L-asparaginase enzyme derived from the bacterium Erwinia Chrysanthemi that is used for the treatment of a cancer of the white blood cells (WBCs) called Acute Lymphoblastic Leukaemia (ALL), a type of cancer that particularly affects children aged 4 months and above, who have developed allergic reactions to E.coli derived asparaginase. Erwinase may be used alone or in combination with other treatments.

Recommended Dosage:
To substitute for a dose of pegaspargase: The recommended dose for each planned dose of pegaspargase is 25,000 international units/m2 administered intramuscularly or intravenously three times a week (Monday/Wednesday/Friday) for two consecutive weeks (total 6 doses). The same dosage recommendations apply to both paediatric and adult patients.

To substitute for a dose of native E. coli asparaginase: The recommended dose of Erwinase is 25,000 International Units/m2 administered intramuscularly or intravenously for each scheduled dose of native E. coli asparaginase within a treatment.

When administering this therapeutic drug intravenously, the desired nadir (pre-dose) serum asparaginase activity (NSAA) levels may not be achieved; consider monitoring NSAA levels and switching to intramuscular (IM) administration if the desired NSAA levels are not achieved with intravenous (IV) dosing.

• Rash, swelling, difficulty breathing, or shock may all occur as suddenly as serious allergic reactions. Every patient should be monitored during and after each dose. After taking the injection, inform me immediately if you feel unwell or notice signs of allergy that lead to additional complications.
• Crisantaspase 10,000 IU (L-asparaginase from Erwinia chrysanthemi) could lead to inflammation of the pancreas, which may result in severe or even life-threatening conditions. Stop treatment if symptoms appear, and contact your healthcare provider right away for evaluation and further medical assistance that may not be needed.
• During treatment, some patients may experience an increase in fatigue, thirst, urination, or even confusion, which are all signs of high blood sugar. Routinely checking blood sugar levels is highly recommended, and treatment adjustments may be needed.
• There is an increased risk of bleeding and blood clots while a patient is on crisantaspase. Symptoms include: discomfort in the legs, chest pain, difficulty breathing, or bruising that is different from normal. The patient must seek medical attention right away during treatment if any of these signs occur.
• This therapeutic drug may cause harm to an unborn baby. Do not use it during pregnancy unless absolutely necessary. Women of childbearing age should use appropriate contraception during treatment and consult their healthcare provider (HCP) if they become pregnant or are looking to conceive soon.
• It is unclear whether Crisantaspase actively enters the breast milk. It may pose a risk to the baby, so breastfeeding is contraindicated during the treatment period. Discuss with your physician whether to cease breastfeeding or this medicine, considering the benefits and risks.
• Using this medicine could influence fertility in males and females. Women and men planning to conceive should see a physician before starting the treatment. Other options for preserving fertility may be considered. It is crucial to comprehend the long-term implications on reproductive health.
• Treatment with Crisantaspase 10,000 IU injection may cause side effects like confusion, dizziness, or fatigue. These can impair the potential to drive or operate machinery safely. Avoid such activities in case you experience these signs and symptoms. Always consider the impacts of the medicine on your condition prior to engaging in hazardous tasks.
• Erwinase contains traces of sodium, and Sodium as well as Glucose. Treating physicians should take this into account in patients with diabetes or heart problems who require sodium or sugar restriction. Tell your physician if you are on a special diet and if you have any specific concerns about the ingredients.

What documents are required to import ERWINASE to India?

ERWINASE (crisantaspase) injections can be imported by patients or government hospitals in the name of the patients only.
The following documentation is required to import the product:

• A valid prescription from a qualified doctor.
• Patients diagnostic reports
• Patient ID proof (issued by the government of India)

How does the order get confirmed?

The order will be confirmed only after the receipt of:

• A valid prescription from the Doctor
• Import permit if applicable

Is ERWINASE available in India?

ERWINASE (crisantaspase injections) is a (prescription drug, prescription medication, or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.

IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator, providing input

• On availability of Erwinase in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune, etc.)
• On availability in Gulf countries (Bahrain, Oman, Qatar, Kuwait, Iraq, Saudi Arabia, and the UAE).
• Medicine Price.
• Finding Genuine and reliable sources from the USA, Canada, Europe, and Australia
• Ensuring 100% transparency.

ERWINASE can be made available to patients, doctors, and hospitals in Mumbai, Goa, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow, and Pune, and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and an import permit.

IPN (Indian Pharma Network) can facilitate the supply of ERWINASE (prescription medicines) to all locations in the world and India after fulfilling the legal requirements (if applicable).

Please contact +91-9310090915 | Toll-Free Number: 1800-889-1064 or write us at info@indianpharmanetwork.in for Erwinase 10,000 IU injection price in India.

We guarantee quality and delivery anywhere in the world as per the buyer’s requirements.

Indian Pharma Network can source ERWINASE (Cancer Treatment Medicines) from across the globe and can supply. Indian Pharma offers its customers worldwide access to the best available treatment.

Indian Pharma Network (IPN) can dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient's address only from New Delhi, India.

What is the Generic Name for the trade name drug Erwinase®?

Crisantaspase is a Generic Name for the trade name drug Erwinase®.

What is the Manufacturer's Name of Erwinase®?

Erwinase® is manufactured by Porton Biopharma Limited.

Are Erwinaze and Erwinase® the same medicine?

Absolutely, both Erwinaze and Erwinase® incorporate the same active component, asparaginase, which is obtained from Erwinia chrysanthemi (also known as crisantaspase). They are practically the same medication for patients with Acute Lymphoblastic Leukemia (ALL) who cannot use the asparaginase derived from E. coli. The difference is only in branding and the approval region. Erwinaze is used in the US and Canada, while Erwinase® is the UK and other countries.

Can Erwinase® be used in place of Erwinaze if one is unavailable?

Mostly yes, but it depends on the local regulatory rules and the doctor’s prescription. They are generally viewed as substitute products, especially during some shortage periods. This is because both medicines contain the same enzyme from the same bacterial source. Although there is a possibility that some regions differ in the available dose and pack size, it is wise to talk to your treating doctor before making the switch.

What is the dosage and form of Erwinase® supplied?

Erwinase® is supplied in 10,000 International Units (IU)/3 mL lyophilized powder per vial for intramuscular (IM) or intravenous (IV) use.

What are the most common side effects of Erwinase® 10,000 IU/3 mL injections?

The most common side effects of Erwinase® injection are diarrhea, vomiting, systemic hypersensitivity, hyperglycemia, nausea, abnormal transaminases, fever, pancreatitis, local reactions, thrombosis, hyperbilirubinemia, and abdominal pain/discomfort.

How much does Erwinase® 10,000 IU/3 mL injection cost in India?

Prices of Erwinase injections may fluctuate over time because of market dynamics and regulatory changes. For the most transparent and latest Erwinase 10,000 IU/3 mL injection cost in India, please Call/WhatsApp +91-9310090915 or send mail to info@indianpharmanetwork.in.

Can Erwinase® 10,000 IU/3 mL injections be available in SAARC countries?

Apart from Gulf countries, Erwinase® can be available in SAARC countries (India, Afghanistan, Maldives, Nepal, Bangladesh, Bhutan, Pakistan, and Sri Lanka). Indian Pharma Network (IPN) can help facilitate the legal supply of Erwinase® injections in these countries. We help ensure legal access to this therapeutic drug through our reliable channels.

Is it safe to buy Erwinase® 10,000 IU/3 mL injections online in India?

Yes, one can buy Erwinase 10,000 IU/3 mL online in India at the lowest price from the Indian Pharma Network (IPN) if this medicinal product is not (yet) registered or available in their country. We can help facilitate the legal supply of Erwinase® injections through legal channels.

What are the storage conditions of Erwinase® 10,000 IU/3 mL injections?

Store unused or unopened vials and cartons of asparaginase Erwinia chrysanthemi at 36°F to 46°F (2°C to 8°C). Protect this medicine from light. Do not use it after the expiration date mentioned on the vial.