Buy Defitelio in India — Price & Availability

What is Defitelio used for?

Defitelio (defibrotide sodium) is an oligonucleotide mixture with profibrinolytic properties that helps protect and stabilise the lining (endothelium) of small blood vessels. In hepatic VOD/SOS, the small veins in the liver become blocked; Defitelio supports the endothelium and helps restore blood flow.

It is approved for:

• The treatment of adult and paediatric patients with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), with renal or pulmonary dysfunction, following haematopoietic stem-cell transplantation (HSCT).

It is the first and only approved treatment for this rare, serious transplant complication. Defitelio is contraindicated with concurrent systemic anticoagulant or fibrinolytic therapy and in patients with known hypersensitivity to it. It is a prescription medicine and must be used under specialist supervision.

Recommended dosage:
The recommended dose of Defitelio is 6.25 mg/kg every 6 hours (four times daily), given as a 2-hour intravenous infusion. Treatment is given for a minimum of 21 days and continued until the signs and symptoms of VOD/SOS resolve, as determined by the treating doctor. The dose is based on the patient’s baseline body weight. Defitelio is given only as a diluted IV infusion. The treating specialist always determines the exact dose and duration.

• Bleeding (Haemorrhage): Defitelio may increase the risk of bleeding. Treatment should not begin in patients with active bleeding and may be paused or stopped if significant bleeding develops during therapy.
• Concurrent Anticoagulants/Fibrinolytics: Defitelio should not be used with blood-thinning or clot-dissolving medicines, as this combination may significantly increase the risk of serious bleeding. Always inform your doctor about all medicines.
• Hypersensitivity Reactions: Serious allergic reactions, including anaphylaxis, have been reported with Defitelio. Stop treatment immediately and seek urgent medical attention if severe allergic symptoms develop.
• Signs of Bleeding: Tell your doctor immediately if you notice unusual bruising, bleeding, blood in your urine or stool, severe headache, or any other unexpected signs of bleeding during treatment.

Common side effects:
Common side effects include low blood pressure (hypotension), diarrhoea, vomiting, nausea, and various forms of bleeding. This is not a complete list — refer to the full prescribing information and your treating doctor.

Patients in India can legally buy Defitelio through the Named Patient Program (NPP) — an import route that allows a medicine not yet registered in India to be imported in an individual patient’s name, on their physician’s prescription. The process is simple and fully documented:

• Share your request — the patient or treating doctor sends the medicine name, required quantity, and destination city.
• Eligibility & document check — we verify the prescription, diagnostic reports, and patient ID against regulatory requirements.
• Receive your quote — a transparent quotation covering medicine cost, logistics, and timeline.
  Regulatory approvals — we assist with the import permit and documentation needed for legal cross-border access.
• Import & delivery — Defitelio is sourced and shipped under validated conditions to the patient or treating hospital.

Documents required to import Defitelio:

• A valid prescription from a qualified transplant or haematology specialist
• The patient’s diagnostic reports (including transplant and VOD/SOS details)
• Government-issued patient ID proof
• An import permit, where applicable

Indian Pharma Network sources Defitelio from reliable manufacturers and authorised supply channels and facilitates supply to patients, doctors, and hospitals under applicable legal provisions. Defitelio vials should be stored according to the conditions stated on the dispensed carton and package leaflet, in the original packaging. All orders are dispensed and checked by registered pharmacists and dispatched after legal requirements are fulfilled.

Is Defitelio available in India?

Defitelio (defibrotide sodium injections) is a prescription medicine that legally requires a doctor’s prescription to be dispensed. As of current publicly available information, Defitelio is not commercially marketed in India.

However, patients in India can legally access Defitelio through the Named Patient Program (NPP) — an import provision that allows a medicine not yet registered in India to be imported in the name of an individual patient, on the prescription of their treating physician.

Indian Pharma Network (IPN) acts as a facilitator under named patient supply, providing input on:

• Availability of Defitelio in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune, etc.) and pathways to access it
• Availability in Gulf countries (Bahrain, Oman, Qatar, Kuwait, Iraq, Saudi Arabia, and the UAE).
• Defitelio price in India under the NPP route
• Sourcing from genuine, reliable channels in the USA, Canada, Europe, and Australia
• Ensuring full transparency throughout the process

Defitelio can be made available to patients, doctors, and hospitals across major cities in India, including Gurgaon, Delhi, Bangalore, Mumbai, Navi Mumbai, Thane, Hyderabad, Mysore, Kerala, Chennai, Coimbatore, Madurai, Kolkata, Ahmedabad, Surat, Vadodara, Pune, Nagpur, Nashik, Jaipur, Udaipur, Lucknow, Kanpur, Gorakhpur, Chandigarh, Mohali, Faridabad, Noida, Ghaziabad, Kochi, Trivandrum, Kozhikode, Thrissur, Kannur, Mangalore, Bhubaneswar, Patna, Ranchi, Raipur, Guwahati, Visakhapatnam, Vijayawada, Goa, Jammu, Srinagar, Dehradun, Bhopal, Indore, Ludhiana, Amritsar, and others — and can facilitate delivery to the patient’s treating hospital. Orders are confirmed only upon receipt of a valid doctor’s prescription and, where applicable, an import permit.

Regulatory approval status:

Defitelio received US FDA approval in 2016 for the treatment of adult and paediatric patients with hepatic VOD/SOS with renal or pulmonary dysfunction following HSCT, with orphan drug designation and priority review. It had earlier been approved in the European Union (2013). As of the current publicly available information, Defitelio is not commercially marketed in India, which is why the Named Patient route is used.

How does Defitelio Import in India work?

Defitelio Import in India can be done through the Named Patient Program (NPP). This means the medicine can be imported on behalf of the patient with a valid doctor’s prescription. Indian Pharma Network (IPN) helps manage the complete process, including approvals and delivery, making sure the medicine reaches the patient safely and legally.

How can I buy Defitelio in India?

Defitelio is not commercially marketed in India, but it can be legally accessed through the Named Patient Program. With a valid specialist prescription, diagnostic reports, and a government-issued patient ID, Indian Pharma Network facilitates compliant import in the patient’s name.

What is the price of Defitelio in India?

Defitelio is not sold on the open market in India, so the cost depends on sourcing, the number of vials required, logistics, and applicable duties at the time of import. A transparent, patient-specific quote is provided once the prescription is verified.

What is Defitelio used for?

It treats adults and children with hepatic veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome (SOS), with kidney or lung dysfunction, following a stem-cell transplant.

Who is a reliable Defitelio supplier in India?

Indian Pharma Network (IPN) is a trusted Defitelio supplier in India, facilitating compliant access through global sourcing channels and structured documentation support for eligible patients under applicable regulatory provisions.

Who manufactures Defitelio?

Defitelio is manufactured by Jazz Pharmaceuticals.

What is the dosage form and strength of Defitelio?

Defitelio is supplied as a 200 mg / 2.5 mL (80 mg/mL) solution in single-patient-use vials, diluted and given by IV infusion. The recommended dose is 6.25 mg/kg every 6 hours for a minimum of 21 days.

Who is an authorized Defitelio importer in India?

Indian Pharma Network (IPN) acts as a Defitelio importer in India. We help with Named Patient Import processes, regulatory documentation, and compliant procurement from leading international manufacturers for patients who need this therapy.

How is Defitelio stored and delivered?

Defitelio vials are stored in the original packaging per the manufacturer’s carton/leaflet instructions and shipped under appropriate conditions to the patient or treating hospital.

Request Defitelio price & availability:

Speak with our patient support team for Defitelio price, quote, and guidance on the Named Patient import process. We respond within 24 hours on business days.

• Call: +91-96548 60915
• WhatsApp: +91-98104 69557
• Toll-free: 1800-1200-365
• Email: info@indianpharmanetwork.in

Disclaimer: Defitelio® (defibrotide sodium injection) is a prescription medicine and should only be used under the supervision of a qualified healthcare professional. Indian Pharma Network is a pharmaceutical trading entity that facilitates access to medicines through legally permissible channels, such as Named Patient import, strictly against valid prescriptions. All trademarks and brand names remain the property of their respective owners (Defitelio® is a registered trademark of Jazz Pharmaceuticals) and are used for identification only. This page is for informational purposes and does not constitute medical advice. Product availability, import requirements, and pricing vary by country-specific regulations.

Because Defitelio is not sold on the open market in India, there is no fixed MRP. The Defitelio cost in India depends on a few factors at the time of import:

• The number of vials required, which is based on the patient’s body weight, the dose (6.25 mg/kg every 6 hours), and the treatment duration (a minimum of 21 days is typical).
• The sourcing country and current ex-market price (USA, Europe, Canada, Japan, China, or Australia).
• Logistics, insurance, and any applicable customs duties or import permit costs.

Get a transparent quote: We provide a written quotation covering Defitelio cost, logistics, and delivery timeline once a valid prescription is shared. Request your Defitelio quote →

Defitelio is a prescription-only medicine. Pricing is shared with patients, caregivers, and treating hospitals against a valid prescription, in line with applicable regulations.

• Defitelio (defibrotide sodium) US Prescribing Information, Jazz Pharmaceuticals.

• US Food & Drug Administration — Defitelio approval (2016).

• European Medicines Agency — Defitelio product information.

• Defitelio- National Cancer Institute

• Defitelio® (defibrotide sodium)  | VOD/SOS 

Content reviewed by the Indian Pharma Network clinical content team. Indications, dosing, and safety information are summarised from the manufacturer’s prescribing information.