Medical Uses
Leukine (sargramostim) is a leukocyte growth factor used:
- To shorten the time to neutrophil recovery and to reduce the incidence of severe and life-threatening infections and infections resulting in death after induction chemotherapy in adult patients aged 55 years and older with acute myeloid leukemia (AML).
- For the mobilization of hematopoietic progenitor cells into peripheral blood for collection by leukapheresis and autologous transplantation in adult patients.
- For the acceleration of myeloid reconstitution after autologous bone marrow or peripheral blood progenitor cell transplantation in adult and pediatric patients aged 2 years and older.
- For the acceleration of myeloid reconstitution after allogeneic bone marrow transplantation in adult and pediatric patients aged 2 years and older.
- For the treatment of delayed neutrophil recovery or graft failure after autologous or allogeneic bone marrow transplantation in adult and pediatric patients aged 2 years and older.
- To increase survival in adult and pediatric patients from birth to 17 years of age acutely exposed to myelosuppressive doses of radiation (Hematopoietic Syndrome of Acute Radiation Syndrome [H-ARS]).
Recommended Dosage:
The recommended dosage of Leukine generally depends on the specific indication and clinical status of the patient. It may be injected either subcutaneously or intravenously, typically once daily, after chemotherapy or a bone marrow transplant. Doctors watch white blood cell numbers and any side effects to decide if the dose needs to be changed. Start administration at an appropriate time after treatment, as guided by clinical protocols. Always use it under the proper supervision of a qualified healthcare provider (HCP) familiar with hematopoietic recovery therapies. Regular monitoring of blood counts and patient condition is important to ensure safe and effective use.