- Medicine Name: Isturisa
- Generic Name: Osilodrostat
- Dosage Form & Strength: Tablets: 1 mg, 5 mg, and 10 mg
- Manufactured By: Recordati Rare Diseases, Inc.
Isturisa is a cortisol synthesis inhibitor used for the treatment of adult patients with Cushing’s disease for whom pituitary surgery is not an option or has not been curative.
Recommended Dosage: Initiate Isturisa dosing at 2 mg orally twice a day, with or without food. Initially, titrate the dosage by 1-2 mg twice a day, no more frequently than every 2 weeks on behalf of the rate of cortisol changes, individual tolerability and improvement in signs and symptoms of Cushing’s disease. If a patient tolerates dosage of 10 mg twice a day and continues to have elevated 24-hour urine free cortisol (UFC) levels more than upper normal limit, the dosage may be titrated further by 5 mg twice a day every 2 weeks.
The maintenance dosage of Isturisa is individualized and specified by titration on behalf of the cortisol levels and patient’s signs/symptoms. The maintenance dosage of isturisa tablets varied between 2 mg and 7 mg twice daily in clinical trials. The maximum recommended maintenance dosage of Isturisa is 30 mg twice a day. Once the maintenance dosage is achieved, monitor cortisol levels at least every 30 to 60 days or as indicated.
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