Aldurazyme (Laronidase)

Aldurazyme (laronidase) is a hydrolytic lysosomal glycosaminoglycan (GAG)-specific enzyme used for the treatment and management of adult and pediatric patients with Hurler and Hurler-Scheie forms of Mucopolysaccharidosis I (MPS I). The medicine is also used for patients with the Scheie form of MPS I with moderate to severe signs and symptoms.
Limitations of Use: The risks and benefits of treating patients with the mild Scheie form remain uncertain. Additionally, the impact of this medicine on central nervous system symptoms associated with the disorder has not been thoroughly studied.

Recommended Dosage: The recommended dosage of Aldurazyme injection is 0.58 mg/kg (body weight) administered via weekly intravenous (IV) infusion. Dilute with 0.9% Sodium Chloride to 50 mL for those weighing 2 kg to 4 kg, 100 mL for 4 kg to 20 kg, and 250 mL for over 20 kg. For those with cardiac or respiratory complications weighing up to 30 kg, a 100 mL dilution with a reduced infusion rate may be considered. Start infusion at 10 mcg/kg/hr, gradually increasing every 15 minutes to a maximum of 200 mcg/kg/hr, maintained for 2 to 3 hours. Resume missed doses promptly. Maintain the weekly schedule. Never double a dose to compensate for missed treatment.

• Serious hypersensitivity, including anaphylaxis, may develop throughout or after administration of Aldurazyme 2.9 mg/5 mL (0.58 mg/mL) injection. Ensure immediate availability of emergency therapies like epinephrine and antihistamines. Monitor patients closely throughout the infusion and be ready to stop in case any reaction occurs.
  Patients with altered respiratory function may experience worsening symptoms during infusion. Pre-existing airway obstruction requires special attention. Use cautiously in such
• patients and ensure respiratory support is available to manage probable acute respiratory distress.
• Cardiorespiratory instability may arise in individuals with serious underlying cardiac disease. Monitor cardiac function throughout the infusion and halt treatment in case acute symptoms occur. Re-evaluate the benefit-risk ratio in those with significant cardiovascular risks.
• Reactions such as rash, fever, or respiratory distress may commonly occur during infusions. Premedicate with antihistamines or antipyretics if required. Discontinue or slow the infusion rate in case serious reactions occur, resuming cautiously after stabilization.
• Aldurazyme should be considered during pregnancy only if the potential benefit justifies the risk to the fetus. Limited data is available; consult a healthcare provider (HCP) for risk assessment and treatment continuity during pregnancy.
• It is unknown whether this therapeutic drug is excreted in human milk. Caution must be imposed when prescribing the medicine to lactating women. Evaluate the potential risks and benefits for both mother and infant, prioritizing infant safety.

What documents are required to import ALDURAZYME to India?
ALDURAZYME (laronidase) injection can be imported by patients or government hospitals on the name of the patients only.
The following documentation is required to import the product:

• A valid prescription from a qualified doctor.
• Patients diagnostic reports
• Patient ID proof (issued by the government of India)

How does the order be confirmed?
The order will be confirmed only after the receipt of:

• A valid prescription from the Doctor
• Import permit if applicable

Is ALDURAZYME available in India?
ALDURAZYME (laronidase injection) is a (prescription drug, prescription medication, or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.

IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator providing input

• On availability of Aldurazyme in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune etc.)
• On availability in Gulf countries (Bahrain, Oman, Qatar, Kuwait, Iraq, Saudi Arabia, and the UAE).
• Medicine Price.
• Finding Genuine and reliable sources from the USA, Canada, Europe, and Australia
• Ensuring 100% transparency.

ALDURAZYME can be made available to patients, doctors, and hospitals in Mumbai, Goa, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow, and Pune and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and an import permit.

IPN (Indian Pharma Network) can facilitate the supply of ALDURAZYME (prescription medicines) to all locations in the world and India after fulfilling the legal requirement (if applicable).

Please contact +91-9310090915 | Toll-Free Number: 1800-889-1064 or write us at info@indianpharmanetwork.in for Aldurazyme injection price in India.

We guarantee quality and delivery anywhere in the world as per the buyer’s requirements.

Indian Pharma Network can source the ALDURAZYME (Cancer Treatment Medicines) from across the globe and can supply. Indian Pharma offers its customers worldwide access to the best available treatment.

Indian Pharma Network (IPN) can dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient's address only from New Delhi, India.

What is the Generic Name for the trade name drug Aldurazyme®?

Laronidase is a Generic Name for the trade name drug Aldurazyme®.

What is the Manufacturer's Name of Aldurazyme®?

Aldurazyme® is manufactured by BioMarin Pharmaceutical Inc.

Is Aldurazyme® approved by the FDA?

Yes, Aldurazyme® is approved by the FDA. Date of first approval: April 30, 2003.

What is the dosage and form of Aldurazyme® supplied?

Aldurazyme® is supplied in Injection: 2.9 mg/5 mL (0.58 mg/mL) of laronidase in a single-dose vial for (IV) intravenous use.

What are the most common side effects of Aldurazyme®?

The most common side effects of Aldurazyme® (occurring in ≥10% of patients) are as follows:
For patients aged 6 months and older: fever, chills, elevated blood pressure, rapid heart rate, and decreased oxygen levels.
For patients aged 6 years and older: rash, upper respiratory tract infections, injection site reactions, heightened reflexes, tingling sensations, facial flushing, and difficulties with venous access.

How much does Aldurazyme® (laronidase) injection cost in India?

Prices of Aldurazyme may vary over time because of market dynamics and regulatory changes. To get accurate and up-to-date information on Aldurazyme 2.9 mg/5 mL (0.58 mg/mL) cost in India, it is recommended that you Call/WhatsApp +91-9310090915 or send mail to info@indianpharmanetwork.in.

Can Aldurazyme® be available in SAARC countries?

Apart from Gulf countries, Aldurazyme® can be made available in SAARC countries (India, Afghanistan, Maldives, Nepal, Bangladesh, Bhutan, Pakistan, and Sri Lanka). Indian Pharma Network (IPN) can help facilitate the supply of Aldurazyme® injections in these countries. We ensure access to this therapeutic drug through the most legal and reliable channels.

Is it safe to buy Aldurazyme® (Laronidase) injections online in India?

Yes, one can buy Aldurazyme online in India at the lowest price from the Indian Pharma Network (IPN) if this medicinal product is not (yet) registered or available in their country. We can facilitate the supply of Aldurazyme® 2.9 mg/5 mL (0.58 mg/mL) injections through legal channels.

What are the storage conditions of Aldurazyme® (Laronidase) injections?

Store vials in a refrigerator at a temperature of 2°C to 8°C (36°F to 46°F). Do not freeze or shake the vials. Keep the vials protected from light, as the medicinal product does not contain any kind of preservatives.