- Medicine Name: Gamifant
- Generic Name: Emapalumab-lzsg
- Dosage Form & Strength: 10 mg/2 mL (5 mg/mL) & 50 mg/10 mL (5 mg/mL) solution in a single-dose vial
- Manufactured By: Novimmune SA
Gamifant (Emapalumab-lzsg) is an interferon gamma (IFNγ)-blocking antibody used for the treatment of adult and pediatric (newborn and older) patients with primary hemophagocytic lymphohistiocytosis (HLH) with refractory, recurrent, or progressive disease or intolerance with conventional hemophagocytic lymphohistiocytosis therapy.
Recommended Dosage: The recommended starting dose of Gamifant injection is 1 mg/kg given as an intravenous infusion over 1 hour twice per week (every 3 to 4 days). Doses subsequent to the initial dose may be increased depending on clinical and laboratory criteria.
Administer this IFNγ-blocking antibody until HSCT (Hematopoietic Stem Cell Transplantation) is performed or unacceptable toxicity. Discontinue treatment when a patient no longer requires therapy for the treatment of HLH.
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