Rivfloza RIVFLOZATM (nedosiran)'
- Name: Rivfloza
- Generic Name: Nedosiran
- Dosage Form & Strength: Injection, 80 mg, 128 mg & 160 mg
- Manufactured: Pyramid Laboratories
Healthcare professionals recommend Rivfloza to lower urinary oxalate levels in children 9 years of age and older and adults with primary hyperoxaluria type 1 (PH1) and relatively preserved kidney function, e.g. eGFR ≥ 30 mL/min/1.73 m2.
Note: Rivfloza is an FDA-approved drug.
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What is the drug Rivfloza used for?
Rivfloza is recommended to lower urinary oxalate levels in children 9 years of age and older and adults with primary hyperoxaluria type 1 (PH1) and relatively preserved kidney function, e.g. eGFR ≥ 30 mL/min/1.73 m2.
Is Nedosiran FDA-approved?
The FDA approved the medicine Nedosiran in 2023.
What are the side effects of Rivfloza?
The common side-effects of Rivfloza are injection site reactions, including erythema, pain, bruising, and rash.
What is the mechanism of action of Rivfloza?
Nedosiran is a double-stranded siRNA conjugated to GalNAc amino sugar residues. After subcutaneous administration, the GalNAc-conjugated sugars bind to asialoglycoprotein receptors (ASGPR) to deliver Nedosiran to hepatocytes.
Nedosiran reduces levels of hepatic lactate dehydrogenase (LDH) via the degradation of LDHA messenger ribonucleic acid (mRNA) in hepatocytes through RNA interference. The reduction of hepatic LDH by Nedosiran reduces the production of oxalate by the liver, thereby reducing subsequent oxalate burden.
What is the price of Rivfloza in India?
To know the Rivfloza price in India, you can call or WhatsApp +91-9310090915 or email info@indianpharmanetwork.in.
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