Xacduro (Sulbactam and Durlobactam)
- Medicine Name: Xacduro
- API: Sulbactam and Durlobactam (co-packaged)
- Dosage Form & Strength: Single-dose kit: 1 g/1 g per kit
- Manufactured By: Innoviva Specialty Therapeutics
Xacduro is a co-packaged for intravenous (IV) use medicinal product containing sulbactam, a beta-lactam antibacterial and beta-lactamase inhibitor, and durlobactam, a beta-lactamase inhibitor, used in patients aged 18 years and older for the treatment of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP), caused by susceptible isolates of Acinetobacter baumannii-calcoaceticus complex.
Limitations of Use: This medicine is not used for the treatment of HABP/VABP caused by pathogens other than susceptible isolates of Acinetobacter baumanniicalcoaceticus complex.
Recommended Dosage: Xacduro is a co-packaged therapeutic product containing sulbactam for injection and durlobactam for injection. The recommended dosage is 1 gram (g) of sulbactam and 1 gram (g) of durlobactam every six hours administered by intravenous (IV) infusion over three hours in adults with a creatinine clearance (CLcr) of 45-129 mL/min. Adjustments to the dosing regimen are recommended for patients with creatinine clearance less than 45 mL/min and for patients with creatinine clearance greater than or equal to 130 mL/min. The recommended length of therapy is 7 to 14 days. The length of therapy should be guided by the patient’s current clinical status.
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