Medical Uses
Halaven (eribulin mesylate) is a microtubule inhibitor used for the treatment of patients with:
- Metastatic breast cancer who have previously been treated with at least 2 chemotherapeutic regimens for the treatment of metastatic disease. Before therapy, it should have included an anthracycline and a taxane in either the adjuvant or metastatic setting.
- Unresectable or metastatic liposarcoma, who have previously been treated with an anthracycline-containing regimen.
Recommended Dosage:
The recommended dosage of Halaven injection is 1.4 mg/m2 administered intravenously over 2 to 5 minutes on Days 1 and 8 of a 21-day cycle. Dosage can be reduced in patients with hepatic impairment or with moderate or serious renal impairment. It is not advisable to mix it with other drugs or administer it with dextrose-containing solutions. Obtain complete blood cell counts and assess for peripheral neuropathy before each dose.
The recommended dose of Halaven injection in patients with mild hepatic impairment (Child-Pugh A) is 1.1 mg/m2, in patients with moderate hepatic impairment (Child-Pugh B) is 0.7 mg/m2, and in patients with moderate or severe renal impairment (creatinine clearance (CLcr) 15-49 mL/min) is 1.1 mg/m2 administered intravenously over 2-5 minutes on Days 1 and 8 of a 21-day cycle.