Introduction of Abatacept:
Abatacept, supplied under the brand Orencia is a well-known medication used for treating rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and Psoriatic Arthritis (PsA). It works by targeting the immune system to reduce inflammation, which is the main issue in RA. This drug helps both adults and children who suffer from these painful and debilitating conditions. It can be used alone or alongside other medicines like methotrexate, but should not be combined with TNF antagonists.
In India, it is estimated that over 10 million people suffer from RA, and treatment options like Abatacept offer hope to many in managing their signs and symptoms and improving their quality of life (QoL). Early intervention with medicines like Abatacept can help reduce long-term joint damage, making it a valuable option in RA care.
How Abatacept Works?
Abatacept is a biologic drug designed to suppress overactive immune responses by inhibiting a protein known as CTLA-4. This protein prevents T-cells (a type of immune cell) from activating excessively, which causes the inflammation seen in autoimmune conditions.
It is produced through recombinant DNA technology, using human cells to create a fusion protein that calms the immune system. Orencia has been approved for use in RA and JIA patients over the age of six, offering hope for both children and adults battling arthritis.
Dosage and Administration:
Abatacept is available in two forms:
- 250 mg powder for intravenous infusion.
- 125 mg/mL solution in a prefilled syringe for subcutaneous injection.
For treating adult rheumatoid arthritis, it can be injected once a week under the skin. In some cases, an initial intravenous (IV) dose is administered to boost its effects. If you are switching from intravenous to subcutaneous (SC) administration, the first injection replaces your next scheduled IV dose.
Side Effects of Abatacept:
Like all medications, Abatacept can cause side effects, though not everyone experiences them. The most common side effects include:
- Headaches
- Upper respiratory tract infections
- Nausea
- Sore throat (nasopharyngitis)
These side effects are usually mild and manageable, but it’s important to speak to your doctor if they persist or worsen.
Warnings & Precautions:
- Treatment with Abatacept should not be used in combination with TNF antagonists, as this can increase the risk of severe infections.
- Patients with chronic infections or conditions that make them prone to infections should use this therapeutic drug with caution.
- Discontinue use immediately if a serious infection develops.
- Patients must be screened for latent tuberculosis (TB) before starting this treatment. If TB is detected, it should be treated before starting the medication.
- Live vaccines should be avoided during treatment and for up to three months after stopping it.
- People with chronic obstructive pulmonary disease (COPD) may be at greater risk of respiratory problems when using Abatacept.
Storage and Handling:
To ensure the effectiveness of this medicinal product:
Powder form: Store in a refrigerator at 2°C-8°C (36°F to 46°F) and protect from light. Do not use past the expiration date.
Prefilled syringe: Store in the original packaging in a refrigerator and do not freeze. Again, protect from light and follow the expiration date strictly.
Stats and Indian Perspective:
In recent years, India has seen a rise in rheumatoid arthritis cases due to factors like lifestyle changes, genetic predisposition, and increasing awareness. A study published in 2021 showed that around 1% of the Indian adult population suffers from RA, translating to millions of patients nationwide. The increasing availability of biologics like Abatacept is a positive step forward, as these treatments can significantly improve the quality of RA patients in India.
Abatacept cost and accessibility are still challenges, but with the growing healthcare infrastructure, these treatments are becoming more accessible, especially in urban centers. Regular follow-ups and careful monitoring are crucial for ensuring effective outcomes.
What is Abatacept used for?
Abatacept is commercially available under the Orencia. It is primarily used to treat rheumatoid arthritis in adults, juvenile idiopathic arthritis in children above 6 years old, and Psoriatic Arthritis (PsA) in people 2 years of age and older. It works by calming the immune system to reduce inflammation and prevent joint damage.
How long does it take for Abatacept to work?
Patients may begin to notice improvements within 12 weeks of starting Abatacept. However, full benefits might take longer, so it’s important to stay consistent with the treatment as advised by your doctor.
Can I take Abatacept with other arthritis medications?
Yes, Abatacept can be taken with other medications like methotrexate or non-biologic disease-modifying antirheumatic drugs (DMARDs), but it should not be used with TNF inhibitors due to a higher risk of infections.
What should I avoid while on Abatacept?
Avoid live vaccines while taking Orencia and for at least three months after stopping the treatment. Also, inform your doctor if you have any infections or if you’ve been exposed to someone with an infection.
Is Abatacept safe for long-term use?
Yes, Abatacept is considered safe for long-term use under medical supervision. However, regular monitoring for infections and other side effects is essential to ensure its continued safety.
How can I buy Orencia in India?
You can buy Orencia online in India through trusted suppliers like Indian Pharma Network (IPN). It’s important to consult with your healthcare provider before purchasing to ensure you are using a trusted source. IPN is one such platform that can help facilitate the supply of Orencia, ensuring that patients receive genuine medication at competitive prices.
Is Abatacept (Orencia) available in India?
Yes, Orencia can be made available in India for treating autoimmune diseases. Send your inquiries to buy Orencia in Lucknow, New Delhi, Noida, Gurgaon, Kanpur, Haryana, Bangalore, Pune, Mumbai, Kolkata, Jaipur, Ahmedabad, Chennai, Hyderabad, Surat and others. However, the availability of this therapeutic drug might vary across regions.
