VORAXAZE (glucarpidase)

Voraxaze (glucarpidase) is a carboxypeptidase used to reduce toxic plasma methotrexate concentration (greater than 1 micromole per liter) in adult and pediatric patients with delayed methotrexate clearance (plasma methotrexate concentrations greater than 2 standard deviations of the mean methotrexate excretion curve specific for the dose of methotrexate administered) due to impaired renal function.

Limitations of Use: This therapeutic drug is not recommended for use in those who exhibit the expected clearance and expected plasma methotrexate concentration. Reducing plasma methotrexate concentration in these populations may cause subtherapeutic exposure to methotrexate.

Recommended Dosage:
The recommended dosage of Glucarpidase is 50 Units per kilogram (kg) as a single intravenous (IV) injection administered over 5 minutes. Flush the intravenous (IV) line before and after administration. For the initial 48 hours after the dose of Glucarpidase, administer the same leucovorin dose given before Glucarpidase. Administer leucovorin at least 2 hours before or 2 hours after the dose of Glucarpidase. Beyond 48 hours after the dose of Glucarpidase, administer leucovorin based on the measured methotrexate concentration. Continue leucovorin until the methotrexate concentration has been maintained below the leucovorin treatment threshold for at least 3 days.

• Treatment with Glucarpidase can cause serious allergic reactions, including breathing complications, rash, or swelling. Patients must be closely monitored during and after administration. Stop treatment quickly in case any symptoms of hypersensitivity occur. Emergency care may be required.
• This therapeutic affects methotrexate blood tests. Standard lab tests may show falsely high levels for 48 hours after glucarpidase is administered. Use only chromatographic methods to measure methotrexate levels after treatment to avoid test results that are incorrect.
• The safety of glucarpidase 1,000 units during pregnancy is not completely known. It may cause harm to an unborn baby. Pregnant women should only use it if clearly required. Healthcare professionals must weigh the benefits against the possible risks before starting this treatment.
• Glucarpidase may pass into human breast milk. As a precaution, avoid breastfeeding during treatment and for a short time afterward. Consult a healthcare provider before breastfeeding after taking this drug to avoid possible risks.
• This medicine is used in children with high methotrexate levels because of kidney complications. It has been studied in pediatric patients. However, children must be monitored closely for any potential side effects during and after treatment with glucarpidase.

What documents are required to import VORAXAZE to India?

VORAXAZE (glucarpidase) injection can be imported by patients or government hospitals in the name of the patients only.
The following documentation is required to import the product:

• A valid prescription from a qualified doctor.
• Patients diagnostic reports
• Patient ID proof (issued by the government of India)

How does the order get confirmed?

The order will be confirmed only after the receipt of:

• A valid prescription from the Doctor
• Import permit if applicable

Is VORAXAZE available in India?

VORAXAZE (glucarpidase injection) is a (prescription drug, prescription medication, or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.

IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator, providing input

• On availability of Voraxaze in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune, etc.)
• On availability in Gulf countries (Bahrain, Oman, Qatar, Kuwait, Iraq, Saudi Arabia, and the UAE).
• Medicine Price.
• Finding Genuine and reliable sources from the USA, Canada, Europe, and Australia
• Ensuring 100% transparency.

VORAXAZE can be made available to patients, doctors, and hospitals in Mumbai, Goa, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow, and Pune, and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and an import permit.

IPN (Indian Pharma Network) can facilitate the supply of VORAXAZE (prescription medicines) to all locations in the world and India after fulfilling the legal requirements (if applicable).

Please contact +91-9310090915 | Toll-Free Number: 1800-889-1064 or write us at info@indianpharmanetwork.in for Voraxaze 1,000 units injection price in India.

We guarantee quality and delivery anywhere in the world as per the buyer’s requirements.

Indian Pharma Network can source VORAXAZE (Cancer Treatment Medicines) from across the globe and can supply. Indian Pharma offers its customers worldwide access to the best available treatment.

Indian Pharma Network (IPN) can dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient's address only from New Delhi, India.

What is the Generic Name for the trade name drug Voraxaze®?

Glucarpidase is the Generic Name for the trade name drug Voraxaze®.

What is the Manufacturer's Name of Voraxaze®?

Voraxaze® is manufactured by BTG International Inc.

What is the dosage and form of Voraxaze® supplied?

Voraxaze is supplied for Injection: 1,000 units as a lyophilized powder in a single-dose vial for reconstitution for intravenous (IV) use.

What are the most common side effects of Voraxaze® 1,000 Units?

The most common side effects of Voraxaze® are paresthesia, nausea and/or vomiting, flushing, hypotension and headache.

How much does Voraxaze® 1,000 Units cost in India?

Voraxaze® is not yet approved in India. However, patients in India can legally access it through the provision called the Named Patient Program (NPP). Prices of Voraxaze injection may fluctuate over time because of market dynamics and regulatory changes. For the most transparent and latest Voraxaze 1,000 Units cost in India, please call/WhatsApp +91-9310090915 or send mail to info@indianpharmanetwork.in.

Can Voraxaze® 1,000 Unitss be available in SAARC countries?

Apart from Gulf countries, Voraxaze® can be accessed through import provisions like the Named Patient Program (NPP) in SAARC countries (India, Afghanistan, Maldives, Nepal, Bangladesh, Bhutan, Pakistan, and Sri Lanka). Indian Pharma Network (IPN) can help facilitate the legal supply of Voraxaze® injection in these countries. We help provide legal access to this therapeutic drug through our reliable channels.

Is it safe to buy Voraxaze® 1,000 Units online in India?

Yes, one can buy Voraxaze 1,000 Units online in India at the lowest price from the Indian Pharma Network (IPN) if this medicinal product is not (yet) registered or available in their country. We can help facilitate the legal supply of Voraxaze® injection through legal channels.

What are the storage conditions of Voraxaze® 1,000 Units?

Store lucarpidase refrigerated at 36°F to 46°F (2°C to 8°C). Do not freeze. Do not use it after the expiration date mentioned on the vial.