Medical Uses
Zytiga (abiraterone) is a CYP17 inhibitor used in combination with prednisone for the treatment of patients with:
metastatic castration-resistant prostate cancer (CRPC).
metastatic high-risk castration-sensitive prostate cancer (CSPC).
Recommended Dosage:
Recommended Dose for Metastatic CRPC: The recommended dose of Abiraterone is 1,000 mg (two 500 mg tablets or four 250 mg tablets) orally once daily with prednisone 5 mg orally twice daily.
Recommended Dose for Metastatic High-risk CSPC: The recommended dose of Abiraterone is 1,000 mg (two 500 mg tablets or four 250 mg tablets) orally once daily with prednisone 5 mg administered orally once daily.
Patients receiving Abiraterone should also receive a gonadotropin-releasing hormone (GnRH) analog concurrently or should have had bilateral orchiectomy. Abiraterone tablets must be taken as a single dose once daily on an empty stomach. Do not eat food 2 hours before and 1 hour after taking this drug. Swallow the tablets whole with water. It is not advisable to crush or chew tablets.