Chemotherapy for Acute Lymphocytic Leukemia

Acute lymphocytic leukemia (ALL) is also named acute lymphoblastic leukemia, which is the most common hematologic malignancy cancer of bone marrow. It is typically featured by the overproduction of immature lymphoblasts.  Acute lymphocytic leukemia (ALL) is a biologically heterogeneous disorder, so that the morphologic, immunologic, biochemical, cytogenetic, and molecular genetic characterizations of leukemic lymphoblasts are […]

Pegaspargase: A Chemotherapy for Acute Lymphoblastic Leukaemia

Background: Pegaspargase (Oncaspar) is a conjugate of monomethoxy polyethylene glycol and L-asparagine amidohydrolase, an asparagine specific enzyme. The L-asparaginase is a kind of an enzyme that catalyzes the conversion of the amino acid L-asparagine into ammonia and aspartic acid. The pharmacological outcome of agent pegaspargase is thought to be based on selective killing of leukemic […]