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Lysodren containing mitotane is an oral adrenal cytotoxic agent. Mitotane is an adrenal cytotoxic agent with an unknown method of action. The drug Mitotane modifies the peripheral metabolism of steroids and directly suppresses the adrenal cortex. Healthcare professionals recommend this medicine to treat inoperable, functional, or nonfunctional adrenal cortical carcinoma. 

Dosage and Administration

Lysodren comes in the form of tablets in 500 mg for oral administration. 

The recommended Lysodren initial dose is 2 g to 6 g orally, in three or four doses daily.

The active ingredient in the tablets is Mitotane, with inactive ingredients microcrystalline cellulose, polyethylene glycol 3350, silicon dioxide, and starch.

Lysodren Side-effects

Before taking the medicine Lysodren (mitotane), one should acknowledge the healthcare professional about the patient’s medical history. 

The most common side effects of Lysodren 500 mg are anorexia, nausea, vomiting, and diarrhea; depression, dizziness or vertigo; and rash.

Warning & Precautions
There are reports of adrenal crisis in patients treated with Lysodren. One should administer hydrocortisone, monitor the patient for escalating signs of shock, and discontinue Lysodren until recovery.
CNS toxicity, includes sedation, lethargy, and vertigo, occurs with Lysodren therapy. Mitotane plasma concentrations exceeding 20 mcg/ml are related to a greater incidence of toxicity. 

Treatment with Lysodren can cause adrenal insufficiency. Institute steroid replacement as clinically indicated. One should measure free cortisol and corticotropin (ACTH) levels for optimal steroid replacement. 
The drug Lysodren can cause fetal harm when administered to a pregnant woman. Healthcare professionals advise females of reproductive potential to use effective contraception during treatment with Lysodren and after treatment discontinuation for as long as mitotane plasma levels are detectable.

Availability of Lysodren: India
Lysodren tablets price in India is reasonable, and one can buy this medicine from numerous certified pharmaceutical suppliers in India. If you want to know more about this drug, contact us at Toll-Free No: 1800-889-1064 or write to us at 
Nitin Goswami

Nitin Goswami joined us as an Editor in 2020. He covers all the updates in the field of Pharmaceutical, Business Healthcare, Health News, Medical News, and Pharma News.

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