Lysodren containing mitotane is an oral adrenal cytotoxic agent. Mitotane is an adrenal cytotoxic agent with an unknown method of action. The drug Mitotane modifies the peripheral metabolism of steroids and directly suppresses the adrenal cortex. Healthcare professionals recommend this medicine to treat inoperable, functional, or nonfunctional adrenal cortical carcinoma.
Dosage and Administration
Lysodren comes in the form of tablets in 500 mg for oral administration.
The recommended Lysodren initial dose is 2 g to 6 g orally, in three or four doses daily.
The active ingredient in the tablets is Mitotane, with inactive ingredients microcrystalline cellulose, polyethylene glycol 3350, silicon dioxide, and starch.
Before taking the medicine Lysodren (mitotane), one should acknowledge the healthcare professional about the patient’s medical history.
The most common side effects of Lysodren 500 mg are anorexia, nausea, vomiting, and diarrhea; depression, dizziness or vertigo; and rash.