Pegaspargase: A Chemotherapy for Acute Lymphoblastic Leukaemia

Background: Pegaspargase (Oncaspar) is a conjugate of monomethoxy polyethylene glycol and L-asparagine amidohydrolase, an asparagine specific enzyme. The L-asparaginase is a kind of an enzyme that catalyzes the conversion of the amino acid L-asparagine into ammonia and aspartic acid. The pharmacological outcome of agent pegaspargase is thought to be based on selective killing of leukemic […]